We collected data on individual perceptions of and plans to accept COVID-19 vaccination in Mozambique. We conducted this fourth round of data collection among study participants in  Sofala, Manica, and Zambezia provinces, Mozambique, between June 2021 and September 2021.* Nearly all respondents report they will take the COVID-19 vaccine when given the chance. Of those expressing hesitancy, the main concern is the perception that vaccinations can be harmful and have potentially negative side effects. Most people believe that they are less likely to contract COVID-19 than others in their community. 100% of local leaders express support for COVID-19 vaccination.